ESC European Society of Cardiology,update

 

My ESC News 17 June 2026 - A Weekly Update of ESC Events & Resources   European Heart Journal: Statins and survival free of incident frailty among older US veterans    Beyond LDL: could statins help protect against frailty? Frailty and cardiovascular disease share inflammatory pathways, yet no drug strategy is established to prevent frailty. In this large retrospective study of 987,301 statin-naïve, non-frail US veterans aged ≥67 years, new statin initiation was associated with a lower risk of incident frailty over 5.3 years after propensity weighting (HR 0.76, 95% CI 0.75–0.76), with similar findings in pre-frail veterans. These data may prompt cardiologists to view statins not only as lipid-lowering therapy, but also as a potential tool to support healthy ageing.   Read the article Cardiovascular Science ESC journals - recent articles   Enjoy free access today to: Cardiovascular Research: Hypoxia differentially affects coronary vessel formation during heart development. Discover European Heart Journal - Cardiovascular Imaging: The prognostic role of pre-treatment global longitudinal strain in patients treated with immune checkpoint inhibitors. Discover European Journal of Heart Failure: Lipid profile patterns in comorbid patients with arterial hypertension and bronchial asthma. Discover European Heart Journal - Cardiovascular Pharmacotherapy: Kidney function and acid–base status as gatekeepers of natriuretic and diuretic responsiveness in chronic HF: insights from the DEA-HF clinical trial. Discover EP Europace: Percutaneous left atrial appendage closure following catheter ablation therapy of atrial fibrillation: outcomes stratified by bleeding risk – a sub-analysis of the OPTION study. Discover European Journal of Preventive Cardiology: Impact of SARS-CoV-2 infection on subclinical myocardial injury in the general population: the Trøndelag Health Study. Discover European Heart Journal - Quality of Care and Clinical Outcomes: Italy passes obesity law: an opportunity to prevent cardiovascular disease across Europe. Discover Translational Science for You   Metabolic control of post-MI fibrosis via a urea cycle–TCA axis Cardiac fibrosis is a common consequence of myocardial infarction and is driven by the activation of cardiac fibroblasts. SGLT2 inhibition has been shown to reduce fibrosis by altering fibroblast metabolism. Multi-omics analyses identified the NAcGlu/ASL/fumarate pathway as a key regulator linking the urea cycle and the TCA cycle. Supplementation with NAcGlu or fumarate improved cardiac function and reduced fibrosis, whereas deletion of ASL worsened outcomes. These findings suggest that targeting fibroblast metabolism may offer a new strategy to prevent adverse cardiac remodelling after MI. Read the full paper for detailed mechanistic insights.   CAR-T therapy is linked to adverse cardiovascular outcomes in older adults CAR-T cell therapies have transformed the treatment landscape of relapsed haematologic malignancies, yet cardiovascular safety in older populations remains insufficiently characterised. In this large US Medicare-based cohort, major adverse cardiovascular events occurred in 5.8% of patients and were most frequently driven by acute heart failure and stroke. Pre-existing cardiovascular disease, particularly cardiomyopathy, atrial fibrillation, and cerebrovascular disease, significantly increased risk. Read more about the need for improved cardiovascular risk stratification and targeted preventive strategies in older adults undergoing CAR-T therapy.     Free chapters   The ESC Textbook of Cardiovascular Nursing: Chapter 2 – Delivering high-quality cardiovascular care Chapter 15 – Looking forward: the future of cardiovascular care The ESC Handbook of Cardiovascular Rehabilitation: Chapter 21 – The EXPERT tool: how to make exercise prescription easy   ESC Chat achieves CE Class I certification   This certification under the EU Medical Device Regulation recognises ESC Chat as a trusted resource for healthcare professionals, providing easy access to ESC Clinical Practice Guidelines. Its responses are grounded in ESC guidance, with a clear structure and referenced sources. Discover how ESC Chat can support your clinical practice.   Standout papers from Australia   Explore 10 standout papers from Australia published in 2025 in the European Journal of Preventive Cardiology. This selection highlights impactful research and regional perspectives driving progress in cardiovascular prevention worldwide.   News from Our Communities ACNAP 2026   Did you catch the latest from Sophia Antipolis? Bringing together over 300 participants from 35 countries, #ACNAP26 gathered the community for two days of practical, hands-on learning, meaningful discussion and lively debate. See our Facebook album.   Heart and Stroke Blog   Stay up to date with heart–brain research through the ESC Council on Stroke Heart and Stroke Blog. Discover the latest article on the OCEANIC-STROKE trial and the evolving role of dual pathway inhibition. Are you interested in contributing by sharing your own clinical case or expert opinion? Submit here.   Post of the Week   Education and Career Development ESC Cardio Talk podcast   From prescription to persistence: guideline-recommended medical therapy in heart failure with reduced ejection fraction With Johann Bauersachs and Samira Soltani, Hannover Medical School, Hannover (Germany). Listen to the podcast.   EAPCI Educational Pathway   Level 1 of the EAPCI Educational Pathway – Coronary Track has now launched! Explore the new coronary track e-learning programme, featuring more than 70 online videos covering the EAPCI Core Curriculum in PCI and preparing you for the EAPCI Certification exam.   HFA Clinical Trials in Heart Failure Course   Are you interested in heart failure research or are you considering a career in clinical investigation? Then join junior clinicians and researchers to learn from key opinion leaders and principal investigators at this course on 18 September in Naples, Italy. Grants and PhD credits are available. Find out more and apply by 22 June.   ESC TV Today – updates and insights from the experts   When should severe tricuspid regurgitation be treated? Stephan Baldus discusses patient selection, transcatheter treatment options, and lessons from the TRISCEND II trial. How can cardiologists recognise carcinoid heart disease? Heidi Connolly reviews the key warning signs, diagnosis, and current treatment strategies. Watch the full episode.   Image of the Week     This week’s image was submitted by Esosa Odigie-Okon, MD, MSc, FACC, University of Texas Medical Branch, Galveston, Texas, USA. What is the diagnosis?   Answer now   Do you have an interesting case to share? Submit it today   Upcoming webinars   TODAY, 17 June: What is cardio-rheumatology? Register Thursday, 18 June: What's new in prediction and prevention of cardiovascular complications in diabetes. Register Thursday, 18 June: The HFA Journal Club - HF hospitalisation as an endpoint in trials: the holy grail? Register Friday, 19 June: New levels of evidence for ESC Guidelines: what changed and why it matters. Register Tuesday, 23 June: Surgical LAA exclusion - from underused opportunity to guideline-supported practice: evidence and practical insights for AF patients. Register         Our Diversity Is Our Strength    politikimx@gmail.com. Contact us